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NQO1 supports the antioxidant network by catalyzing the two-electron reduction of quinones to hydroquinone, thereby bypassing semiquinone intermediates that can undergo redox cycling

NAD+ itself is essential to cell metabolism, but high quality human studies on injected low doses are still limited

Combined administration of mitragynine with morphine increases antinociception compared with morphine alone and prevents the development of morphine tolerance 19

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