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Comment: Several commenters expressed concern with CMS' proposal to require at least 50 percent of prepaid shared savings be spent on direct beneficiary services not otherwise payable in Traditional Medicare, because they believe it puts doctors in the direct role of supplying insurance benefits to Medicare recipients, akin to serving as a Medicare Advantage plan

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NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex involved in the development of immune and inflammation-related diseases

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