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Furthermore, adaptive plasticity processes in the lesioned hemisphere function together with remote neuronal networks, i.e., in the homotopic regions of non-lesioned hemisphere (Cramer, 2008

EPMA Journal 8:357376

This protective effect involves TUG1 binding to the RNA splicing factor 1, which stabilizes ACSL4 mRNA- a key driver of lipid peroxidation- highlighting a novel axis for therapeutic intervention

As a representative example of this advanced in vitro approach, in 2021 Peter Ertls group established a synovium-on-chip platform that leverages patient-derived FLS