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Interestingly, OBP6 protein did not bind to the pheromones 2-ethyl-3,5-dimethylpyrazine and 2,4,6-trimethylpyridine (Wei et al., 2021)

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It appears that extensive oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids might modify membrane structure and increase membrane permeability, eventually resulting in plasma membrane rupture in response to accumulation of lipid-ROS, e.g., lipid hydroperoxides

2020;11:366.[DOI] 25

now, novel treatment strategies directly targeting the ion channel abnormality are becoming available and it will be important to evaluate how these treatments affect disease progression and the quality of life of patients