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Symptoms, which are variable, include hair loss, weight gain, fatigue, low energy, constipation, as well as muscle weakness

The occurrence of purpura, ecchymoses, and petechiae suggest the occurrence of either thrombocytopenia or other bleeding disorders

However, whether host-derived ROS could directly kill pathogens is still a matter of debate, since several studies argued that intracellular ROS level in phagosomes was insufficient to kill pathogens (Slauch, 2011

101 Moreover, several phase II trials have shown that clioquinol is capable of reducing A aggregation and improving cognitive function, but fail to provide sufficient evidence of a positive benefit in a larger trial

In the course of age-related degeneration of the spiral ganglion cells, the autophagy activator rapamycin rescues dying neurons and preserves ganglion cells [73]

[Research updates: the mechanism of autophagy in inflammatory bowel disease]