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[PMC free article: PMC3111292] [PubMed: 21606363] 844

Hepatic mRNA levels of the SREBP target genes, namely, hydroxymethylglutaryl-CoA reductase ( HMGCR ), SREBP2, proprotein convertase subtilisin/kexin type 9 ( PCSK9 ) and low-density lipoprotein receptor ( LDLr ) were significantly increased in the HFD group relative to the ND group but were significantly decreased by Godex (Fig