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A phase II clinical trial with MR309 has been completed in patients with colorectal cancer receiving OHP therapy [194]

Thus, the functional outcome of TBK1 activity appears to be highly context-dependent, varying with the identity of the autophagy receptor and cargo

P., Stupar, R

Preclinical studies show it enhances insulin sensitivity, promotes fat oxidation, improves exercise capacity, and counters age-related metabolic decline [1] [4]