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Kaya S., Kaya C., Computational and Theoretical Chemistry , 2015 , 1060 , 66

More studies are needed to better understand the role of FOXO in the pathogenesis of neurodegenerative diseases and its potential as a therapeutic target for PD treatment

Lab animals have been bred or engineered that carry versions of mitochondrial DNA that increase free-radical production (Yardeni et al., 2019)

However, it would be interesting to assess CD38 expression in T cells from symptomatic familial AD individuals, and whether CD38 could also serve as an early diagnostic marker in sporadic AD, which accounts for 9095% of AD cases 1

188 Conversely, asprosin, interleukin-6 (IL-6), TNF-, and IL-12p70, which are predominantly secreted by visceral adipose tissue, 189 impair insulin signaling in muscle and liver and drive non-alcoholic fatty liver disease 190 via pro-inflammatory mechanisms