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Collectively, our in vivo and in vitro findings are consistent with TMAO aggravating kidney fibrosis due to ERK1/2 hyperactivation synergistically, probably with activation of the TGF-1-mediated SMAD3 pathway causing a secondary hit in our disease model

Albers E, Nijhof LN, van der Berkelbach EE, van de Putte EM, Nijhof SL, Knoop H

Inhibiting stearoyl-CoA desaturase ameliorates alpha-synuclein cytotoxicity

5 L KRAS G12C -GDP&GDP was added into each assay well and incubated for 15 min