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1,4 Hyperglycemia, dyslipidemia, and insulin resistance activate various metabolic pathways, resulting in oxidative stress, mitochondrial dysfunction, inflammation, and microvascular damage, culminating in neuronal injury, Schwann cell damage, and myelin sheath degeneration

Plates were coated with 0.01% PLO overnight at 37 C, followed by a second coating in 5 g/ml laminin for approximately 4 h at RT

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Many patients report less fatigue and better focus after an iv therapy session