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The peptides small size and charge profile allow it to penetrate the stratum corneum, though penetration efficiency depends heavily on the vehicle

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8.Sikiri P, Seiwerth S, Grabarevi , Ruman R, Petek M, Jagi V, et al

A randomized, controlled, blinded human trial of GHK-Cu monotherapy, with a vehicle-only control (and a needling-plus-vehicle arm if a procedure is used), objective endpoints such as blinded global photography and target-area hair counts over at least several months, adequate statistical power, pre-registration, and independent replication

While 0 generally indicated no changes, the lesions were subsequently scored as follows: 0-3, edema (1- weak diffuse and/or perifocal

JHEP Rep