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doi: 10.3389/fendo.2020.601290 Received 31 August 2020 Accepted 12 November 2020 Published 14 December 2020 Volume 11 - 2020 Edited by Magdalene K

doi: 10.1038/s41392-025-02297-6 356

This work is supported by the Natural Products & Nanobiotechnology Research Lab, Saveetha Institute of Basic Medical Sciences (SIBMS), Saveetha Institute of Medical and Technical Sciences (SIMATS), (Saveetha University), Thandalam, Chennai, Tamil Nadu 602105, India Conflict of interest The author declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

In summary, the action of valproate in neural systems is complex, with one aspect including downregulation of PKC signaling, which overlaps with symptom amelioration of manic states in animal models, suggesting that modulation of PKC overactivity is a mechanism that is favored by valproate

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