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doi:10.1007/s10522-015-9570-3

Lippman SM, Heymach JV

Reduced GST activity may exacerbate oxidative stress and contribute to -cell dysfunction and insulin resistance (Hurrle and Hsu, 2017)

The main exception to this rule is the GLP-1 class (like semaglutide, tirzepatide, or retatrutide), which may be used for longer under proper supervision since the studies and pharmacology support extended duration