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Full-length thymosin beta-4 (T4) is a 43-amino acid endogenous peptide that functions as the primary G-actin sequestering protein in mammalian cells and maintaining the cellular pool of polymerisation-competent actin monomers and regulating cytoskeletal dynamics through its central LKKTETQ actin-binding motif

Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinsons disease

For instance, lipofuscin granules can sequester regulatory proteins such as Pin1, a prolyl isomerase essential for tau dephosphorylation [122]

Certain studies on human sperm demonstrate a negative correlation between copper content in seminal plasma and sperm motility parameters [172, 173]

While HK2 has limited expression in most normal tissues, it is frequently overexpressed in various cancer tissues and has recently been found to be overexpressed in ischemic stroke brain tissues (68, 71, 72)