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Previous reports have shown that alkylating agents such as MNNG and MMS, induce an increase in phosphorylation and protein level of p53 through functional protein complexes of mismatch repair in DNA damage response [82,87]

de Pablo, P

doi: 10.1038/nature07534

However, excessive ROS may cause harmful effects through oxidative modifications of cellular components, particularly damaging proteins, lipids, carbohydrates, and nucleotides ( The primary cellular sources of ROS include mitochondria and NADPH oxidase (NOX) ( 2 )

The breakdown of the intestinal barrier also results in increased risks for the development of bacteremia/septicemia

These four small G proteins bind to GTP/GDP and exhibit GTP hydrolase activity