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On the contrary, alterations in the C-terminal seemed less critical for activity and for instance a deletion of the C-terminal phenylalanine residue of 1 had only a minor impact and the binding affinity was essentially maintained (Sardinia et al., 1993

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Glutamine is one of the antioxidants that work to neutralize the effects of free radicals

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Rather than acting merely as a mutagen, ROS in the mature TME functions as a critical second messenger that maintains the oncogenic phenotype

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