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More importantly, this pro-inflammatory oxidative environment alters astrocytic physiological states, potentially impairing their ability to form TNTs or generate EVs, thereby directly inhibiting mitochondrial transfer mechanisms

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iScience 27 , 110359 (2024)

Moreover, inhibition of mGluR5 was shown to enhance the potency of chemotherapeutic agents in hepatocellular carcinoma cell lines and attenuate chemotoxicity over DNA damage by downregulating Ca 2+ -dependent MAPK signaling in the normal liver (76)

If being solely relied upon due to an absence of intrinsic factor, much higher doses of B12 are required than can be found in animal foods, fortified foods, or multivitamins

The tissues were fixed in 4% paraformaldehyde and then embedded in paraffin