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This resulted in an increase in annual B 12 testing expenditure from $3.0 million to $5.6 million during the same time period

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This indicates that the anti-inflammatory effects of EC largely depend on the integrated action of its microbial metabolites rather than the isolated activity of the parent compound itself ( 5 Limitations and future perspectives Despite its significant biological activities, EC faces major challenges in clinical application, primarily due to its low bioavailability