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Description

The acetyl modification makes the molecule naturally stable across pH ranges and resistant to oxidation

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Cos7, or HEK293 cells were transiently transfected with the indicated plasmids using Lipofectamine 2000 or 3000 (Invitrogen) as per manufacturers instruction

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These results validated that ZZW-115 worked efficiently in blocking the nuclear translocation of NUPR1 in our culture model and that inhibition of NUPR1 nuclear translocation induces cell death in phBECs, indicating an important protective role in bronchial epithelial cells

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