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Hydroxyurea therapy

The stably transfected cell, TPC-1 cells with FTO over-expression, and controlled cells with empty vector were collected

Mechanisms by which the TCA cycle promotes ferroptosis include the generation and export of citrate to drive the synthesis of new substrates for lipid peroxidation 16 , and the stimulation of the electron transport chain (ETC) 15

N-acetyl L-cysteine (NAC) This amino acid is essential to the production of L-glutathione

N = 7 mice/experimental group (two independent experiments)

Overall, TF signaling, a marker of breast cancer progression, represents a promising target for developing breast cancer treatments