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Acknowledgements This research was funded by the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (2022R01002), the National Key R&D Program of China (2022YFA1105200), the Key Research and Development Project of Zhejiang Province (2020C03035), the Opening Foundation of the State Key Laboratory of Transvascular Implantation Devices (SKLTID2024005), Postdoctoral Fellowship Program and China Postdoctoral Science Foundation (BX20240304) and Postdoctoral Science Preferential Funding of Zhejiang Province (ZJ2024086)

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Environmental chemicals can affect the composition and/or the metabolic activity of the GI microbiota The composition, diversity and enzymatic capacities of the gut microbiota are readily affected by various environmental factors, such as the hosts lifestyle, diet and use of antibiotics

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The NK cells were centrifuged and washed 3 times in ice-cold 1X PBS (515 G, 4 C, 5 min), counted using a hemocytometer, and 1 10 5 cells were incubated with 1 g of isotype or anti-human NKG2D antibody (1D11, BioLegend) for 1 h on ice

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