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The soft callus is visible on X-rays as a cloudy mass surrounding the fracture line, and its size often correlates with eventual healing success

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Fibroblast-like synoviocytes (FLS) in the intimal layer adopt a pro-inflammatory phenotype under chronic stimulation, secreting cytokines such as IL-1, TNF-, IL-6, and chemokines that attract monocytes and perpetuate synovitis