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Chronic Acetaminophen Ingestion Can Improve Blood Glucose Control Although a toxic dose of acetaminophen (3 h following 500 mg APAP/kg body weight) can rapidly induce hyperglycemia (Hinson et al., 1984) and acute liver failure secondary to clinical acetaminophen overdose can further impair the peripheral uptake of glucose (Clark et al., 2001), recent animal studies have demonstrated that acetaminophen, when taken at lower dosages (2030 mg/kg body weight) exhibits an ability to lower blood glucose levels in several animal disease models, including diabetes, high-fat (HF) diet induced obesity, and aging

The consequence is microvascular dropout, reduced oxygen delivery, and increased diffusion distances for nutrients and signaling molecules, particularly in vulnerable tissues such as the brain, muscle, and gastrointestinal tract

Sun, F., Zhou, J

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