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In some cases, patients are bound to face problems of skin rashes or even skin irritation at the area of injection

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Furthermore, an advantage of curcumin is that it shows no toxicity (10400 mg/m 2 ) [98], which provides beneficial opportunities for its use in the treatment of Parkinsons disease

Author contributions SR: Conceptualization, Data curation, Investigation, Methodology, Project administration, Visualization, Writing original draft

Compared with the free enzyme, the encapsulated PLGA NPs enhanced the delivery of the enzyme to the organs, especially the brain tissue (Figure 10B-D), and were superior to the coated PLGA NPs, providing guidance for future applications

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