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Oxidative Med Cell Longev 2022:5418376 Pan M, Cheng Z w, Guang HC, Qing YZ, Jun SL, Chen H et al (2022) Long-term exposure to copper induces mitochondria-mediated apoptosis in mouse hearts

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Abstract Despite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the host on protecting the joint life quality and minimizing health risks

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J Clin Endocrinol Metab 2005

That said, the LA/Ao clearly has no useful role whatsoever when examining only a single dog's heart to determine if that dog's LA has enlarged between two consecutive echo exams