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Our findings indicate that FOXO4-DRI promotes apoptosis in senescent cells by disrupting the FOXO4-P53 interaction, thereby releasing and phosphorylating P53, which then translocates to the cytoplasm

Aspartate, asparagine, threonine, methionine, proline, and glutamine, which are associated with the aspartate and glutamate metabolic pathways, are involved in many biochemical processes, such as the biosynthesis of other amino acids, nucleotide metabolism, the TCA cycle and intermediate glycolysis, and hormone biosynthesis (Han et al

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Therefore, caution should be taken when extrapolating findings from this work to individuals who were infected after completing their vaccination or were infected with more recent SARS-CoV-2 variants