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Brain Res Bull 152:1118 Liu S, Pi J, Zhang Q (2022) Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

AF enhances HMGB1 and CRT release, boosts DC activation, and improves ICB efficacy

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The importance of ROS on NF-B activation is further supported by studies demonstrating that activation of NF-B by nearly all stimuli can be blocked by antioxidants, such as L-cysteine, N-acetylcysteine (NAC), thiols, green tea polyphenols, and vitamin E [185, 186], although this might be not very specific because antioxidants have multiple targets [187]