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10.1016/j.bbi.2017.01.011 Brain Behav

They regulate fibroblast activation, failed epithelial repair, immune cell reprogramming, and ECM accumulation, demonstrating consistent antifibrotic potential in preclinical systems [100,101]

Collectively, multifunctional metabolic enzymes act as pivotal hubs linking metabolic reprogramming to therapeutic resistance, serving as upstream initiators of signaling cascades that drive drug tolerance in CRC