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These Cu-MOFs can effectively deplete intracellular GSH, downregulate the expression of glutathione peroxidase 4 (GPX-4), and produce OH to further promote lipid peroxidation, thereby inducing ferroptosis in tumor cells [97]

Supports Fatty Acid Metabolism*

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For the gold atoms the 19-e - relativistic effective core potential (19-e - RECP) from the Stuttgart group 51 taking into account scalar relativistic effects has been used

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doi: 10.1146/annurev.biochem.76.052305.091720 60 AndersonCABoucherGLeesCWFrankeAD'AmatoMTaylorKDet al