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For reproductive toxicity evaluation, Sprague Dawley rats (26 males and 26 females) received doses at 60, 180, or 540 mg/kg every 28 days (males on days 1, 29, and 57

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Yamashita S, Arai H, Bujo H, Masuda D, Ohama T, Ishibashi T, et al

This would allow for the benefits of fragment 176-191 to be realized without having any impact on normal GH secretion

Glucose metabolism mediates type I IFN secretion through enhancing NF-kB expression 65 and epigenetic acetylation 66