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Lowest-observed-adverse-effect level (LOAEL): 2000 mg/kg/day

This strategy works upon intracellular conversion of a relatively non-toxic prodrug into a toxic drug by a xenobiotic origin enzyme and has been referred to as genetic prodrug activation therapy (GPAT) [45]

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Cervical tumors overexpress matrix metalloproteinases (MMP-2, MMP-9), cathepsins, and hyaluronidasesenzymes involved in ECM degradation, invasion, and angiogenesis [203, 204]