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CHOP inhibits the activity of anti-apoptotic proteins Bcl-2 and Bcl-xL, disrupting the balance between apoptosis and anti-apoptosis within the cell, making it easier for the cell to undergo apoptotic outcomes (Urano et al., 2000)

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Concurrently, Fe 2 activates lipoxygenases (LOXs), a family of iron-containing enzymes that catalyze the dioxygenation of polyunsaturated fatty acids (PUFAs)

et al.) 571-657 (Cambridge University Press, 2013)