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Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

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It is estimated that PD affects at least 1% of the population over the age of 60 (Zafar and Yaddanapudi, 2023)

This selective effect of the MSO/CB839 combination contrasts sharply with the general toxicity observed with direct pharmacological inhibition of upstream regulators like FOXO1 (using AS1842856), which non-selectively reduced the viability of all cell lines, including parental wild-type cells (Appendix Fig

These findings underscore the tight linkage between oxidative stress in endothelial cells and the development of AD

They are produced by natural metabolic processes and external factors like pollution, UV rays, and poor diet