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In a unilateral PD rat model, rats were subjected to either 1 or 4 weeks intermittent moderate treadmill exercise (Fernandes Ferreira et al., Another study using a rodent model showed that exposure to 6-hydroxydopamine (6-OHDA) led to a reduction of mitochondrial factors adenosine monophosphate (AMP)-activated protein kinase, PGC-1, and tyrosine hydroxylase (TH), and increased expression of silent information regulator T1, TFAM, and p53 (Rezaee et al., 2019)

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Typical duration Often 412 weeks depending on season and goal, with reassessment