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doi: 10.1124/pharmrev.121.000408 16

At the molecular level, EJC-independent NMD still depends on the same core NMD factors, particularly UPF1, and its regulation by SMG1-mediated phosphorylation [42]

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This review starts with an overview of the BBBs anatomical structure and physiological roles, and then explores the mechanisms, both endogenous and exogenous, that facilitate the NP passage across the BBB

Despite this relatively short half-life in circulation, the downstream metabolic effects persist for significantly longer due to the sustained activation of lipolytic enzymes and metabolic pathways initiated by the peptide

, 2010) and chronic hepatitis C (Malaguarnera et al