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Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187

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doi: 10.1073/pnas.94.6.2507 90 BoullandMLMarquetJMolinier-FrenkelVMllerPGuiterCLasoudrisFet al

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Like GLP-1, glucagon slows how quickly your stomach empties, further suppressing appetite, while its metabolic effects boost energy expenditure