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Excessive ROS triggers oxidative stress Although ROS production in mitochondria is in balance with an intracellular antioxidant system under physiological conditions, the balance is easy to be disrupted under pathological conditions, such as radiation, hypoxia, cytokines, hyperlipidemia, and hyperglycemia, which results in the accumulation of ROS, facilitating oxidative stress, cell damage, and diseases, such as cancer, cardiovascular disease, neurological disease, respiratory disease, and so on

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10.1016/j.nano.2012.11.010 118 ManujaA.KumarB.AthiraS.SarkarP.RiyeshT.KumarN.et al (2022)

Lethargy Muscle weakness Mood swings Memory loss Tingling in the fingers and toes Weight gain Though B12 is found in many different foods, including meat, eggs, and fortified grains, it may be difficult to get enough of this nutrient from your diet, especially if you are following a specific diet for weight loss

Mutagenicity and carcinogenicity of selected chloroacetanilides and related compounds