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Firstly, it inhibits NMDA receptors, critical for Ca 2+ influx mechanisms, which leads to reduced BDNF concentrations (Wang et al., 2016a) (Figure 2, number 3 and 4)

doi:10.1021/acs.jmedchem.5c01008

10.1111/tpj.13388 Plant J

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J Pineal Res 55(3):275286 Zhu H, Jin Q, Li Y, Ma Q, Wang J, Li D, Zhou H, Chen Y (2018) Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca 2+ ]c/VDAC-[Ca 2+ ]m axis by activation of MAPK/ERK signaling pathway