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We know that long-duration proton pump inhibitor (PPI) use is often associated with lower magnesium levels and deficiency. Meacham says

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[DOI] [PubMed] [Google Scholar] 65.Zhu S.Y., Jiang N., Yang J., Tu J., Zhou Y., Xiao X., Dong Y

The diversity of extracellular vesicles (EVs) (338, 339) and the minimal uniformity regarding the methodologies for their isolation, purification, and characterization (340) make the application of EVs in the clinical setting challenging