Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4) propargyl-acetyl Product Name DOTA-tris(t-Bu)ester-PEG2-C2-propanamido-maleimide Synonyms CAS

Product Name DOTA-tris(t-Bu)ester-PEG2-C2-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C41H71N7O12 Molecular Weight 854

with the addition of sulfonic acid groups that enhance its solubility in aqueous environments

DMF Shipping Conditions Shipped on gel packs Storage Conditions Store at -20°C and protected from light Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

8 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

392 Purity (HPLC) >= 95% Solubility DMSO

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4) propargyl-acetyl Product Name DOTA-tris(t-Bu)ester-PEG2-C2-propanamido-maleimide Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived from