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This finding underscores the involvement of the glutamate signaling pathway in ALS (Spalloni et al., 2013)

Fail 46 (2), 2359033

This number of observed edges was significantly greater than expected for a random network of similar size (P1x10-16), indicating that the encoded proteins are more interconnected than would occur by chance and are likely involved in biologically related processes

The lactate produced by glycolysis is then transported out of astrocytes through monocarboxylate transporters (MCT1 and MCT4) and taken up by neurons via MCT2 (Figure 1)

Swisher SG , Hofstetter W, Wu TT, Correa AM, Ajani JA, Komaki RR, Chirieac L, Hunt KK, Liao Z, Phan A, Rice DC, Vaporciyan AA, Walsh GL, Roth JA

Studies on the mechanism of ozone inactivation of erythrocyte membrane (Na+ + K+)-activated ATPase

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