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doi: 10.3389/fonc.2022.1024789 78 EpelmanSLavineKJRandolphGJ

JAMA Psychiatry 72 , 603611 (2015)

Nuclear translocation of HIF-2 leads to the activation of target genes, including the iron uptake genes TFR1 and DMT1 in enterocytes ( Genetic alterations in JHDMs [Jumonji-C (JmjC) domain-containing histone demethylases] have been identified in various human cancers

High throughput screening has identified three inhibitors, -catenin responsive transcription inhibitor 3 (iCRT3), iCRT5, and iCRT14 specifically known to inhibit -catenin and TCF interaction (Lepourcelet et al., 2004

Transforming growth factor-1 and cigarette smoke inhibit the ability of 2-agonists to enhance epithelial permeability

The blue curve represents a healthy or early-injury lung: broad balanced zone, high efficiency