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Eur J Pharmacol [Internet]

A hypoxic environment causes hepatocytes and HSCs to release VEGF, which stimulates LSEC proliferation and remodels the sinusoidal network

When GSTA4-4 was overexpressed in mouse pancreatic islet endothelial (MS1) cells, the concentration of acrolein producing 50% reduction in cell viability (LC 50 measured by MTT absorbance) increased from about 5 M for the wild-type cells to about 38 M for the transfected cells overexpressing GSTA4-4