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At the same time, reduced IDO activity reduced kynurenine and further weakened peripheral immune tolerance, which played a driving role in the hypothyroidism immune disorder caused by the imbalance of the whole gut microbiota (Clarke et al., 2017)
[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Mohanty A., Bashir B., Kolekar K.A., Acharya A., Gulati M., Chaitanya M., Gupta M., Patle D., Gupta G., Singh S.K
Factors such as poor nutrition, chronic stress, exposure to environmental toxins, and the natural aging process can deplete glutathione (Cymbiotika, 2025)
Different depression phenotypes may yield conflicting results, and certain clinical features of MDD influence these pathways [10]
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