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Although the retro-inverso approach may fail to accurately reproduce biological function in the context of helical structures (e.g., p53 or HIV-1 proteins), certain exceptionssuch as the binding of a p53-derived retro-inverso peptide to its regulator MDM2demonstrate that well-designed D-peptides can, in specific cases, effectively mimic the function of the original peptide

Immunity (2002) 16:76977.10.1016/S1074-7613(02)00323-0 11 BensingerSJBradleyMNJosephSBZelcerNJanssenEMHausnerMAet alLXR signaling couples sterol metabolism to proliferation in the acquired immune response

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Consequently, the major decomposition products of superoxide and peroxynitrite formation in the phagosome are ultimately hydrogen peroxide and nitrite

Stability studies and in vivo analysis were performed on Swissalbino mice

doi: 10.1016/j.febslet.2006.03.071 52 HeL.GuoY.DengY.LiC.ZuoC.PengW