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Efficacy and safety of exogenous ketone bodies for preventive treatment of migraine: a study protocol for a single-centred, randomised, placebo-controlled, double-blind crossover trial

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The uptake and accumulation of cadmium in plants generate reactive oxygen species (, H 2 O 2 , and OH ) by replacing the cofactors of essential-metal ions in metalloproteins via the Fenton reaction (Loix et al., 2017), which, in turn, damages cell membranes through lipid peroxidation and inhibits the biosynthesis of cellular biomolecules required for plant life (Yan et al., 2015)

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The median age of patients was 48 years (IQR 40, 57) and 68.6% were male