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Furthermore, the formation of blood vessels in matrigel injected in mice showed -CBT-diol significantly reduced hemoglobin concentration (about 80% reduction) values when compared with vehicle-treated control, indicating -CBT-diol is an effective angiogenesis inhibitor and would be useful to control of VEGF-dependent breast malignancies in the future ( In liver cancer, -CBT-diol inhibited the proliferation of HepG2, SMMC-7721 and HL-7702 tumor cells, reduced the formation of carcinoma cell clones, disrupted the cell cycle by significantly increasing S phase, induced cell apoptosis by regulating p53-PUMA, PI3K-Akt, and IL-1-NF-B-IAP pathways (Yuan et al., 2019)