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(1974) was complicated by the use of other antidotes

Artif Cells Nanomed Biotechnol (2021) 49(1):8395

This promotes additional breakdown of the intestinal barrier, exacerbating tissue injury and potentially leading to systemic infection (Arosa et al., 2022

Given that their high toxicity may provoke serious side effects, researchers are proposing different ways to reduce their toxicity without decreasing their efficacy