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Neurotoxicol Teratol 48:917 Jin Y, Zhang S, Tao R, Huang J, He X, Qu L, Fu Z (2016) Oral exposure of mice to cadmium (II), chromium (VI) and their mixture induce oxidative-and endoplasmic reticulum-stress mediated apoptosis in the livers

Functional milestones Functional improvements often tell you more than pain scores alone: Walking distance without symptom increase Sitting tolerance (minutes before symptoms worsen) Ability to perform previously limited activities Sleep quality (reduced nighttime symptoms indicate improvement) Medication usage (decreasing NSAID use is a positive sign) When to adjust the protocol If there is no improvement after 3 to 4 weeks on a BPC-157 only protocol, consider adding TB-500 for systemic support

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FJ: Writing review and editing, Project administration, Supervision, Writing original draft, Conceptualization, Funding acquisition

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Hepatology 57 , 13431356 (2013)