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The drug-specific metabolic reprogramming of residual cancer cells after in vivo treatments was maintained in ex vivo cultures for many cell generations, in the absence of any chemotherapeutic selective pressure, also suggestive of a heritable epigenetic mechanism underlying the persistent metabolic reprogramming

Consistent with the prior savings adjustment scaling factor, 50 percent represents an appropriate multiplier in this context because it represents a middle ground between the maximum sharing rate of 75 percent under the ENHANCED track and the lower sharing rates available under the BASIC track

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Continuing through this plateau typically leads to resumed improvement

H.ClaytonP.WongG.CampbellS

H.MichaudJ.BuotV.StefanchikB.PlotkinM